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Viagra has been prescribed "off-label" to treat Raynaud's disease, in which the fingers and toes become cold and numb, and, in combination with doxorubicin, to treat prostate cancer.34. PadmaNathan H, Steers WD, Wicker PA "Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction: A double-blind, placebo-controlled study of 329 patients." Int J Clin Pract 52 (1998): 375-9

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In healthy male volunteers, there was no evidence of a clinically significant effect of azithromycin (500 mg daily for 3 days) on the systemic exposure of sildenafil or its major circulating metabolite.

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