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Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.9 users found this comment helpful. Did you? Yes No Report as inappropriate cialis duration How fast does it work? Varies by person, but users are recommended to take the pill at least 30 minutes to an hour prior to sex. Levitra label says to take it 60 minutes before sexual activity, but studies show it can work faster. May be more likely to work the first time. If you are older than 65 or have liver problems, your doctor may start you on a lower dose of LEVITRA.Since both Viagra and Levitra have moderate vasodilatory and hypotensive effects, they should not be given in the presence of marked arterial or orthostatic hypotension, and should only be administered with caution in aortic stenosis or hypertrophic obstructive cardiomyopathy.

dapsone price of levitra 48. Goldmeier D, Lamba H "Prolonged erections produced by dihydrocodeine and sildenafil." BMJ 324 (2002): 1555

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure), stroke in the past 6 months, kidney disease, liver disease, high or low blood pressure, a severe loss of body water (dehydration), penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease), history of painful/prolonged erection (priapism), conditions that may increase the...Prolonged Erection

Cool cat July 19, 2015 how does levitra work You should not eat food or take medications that contain nitrates such as processed meats or nitroglycerin.

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